12/30/2023 0 Comments Acetaminophen and caffeine structure![]() Souri, E., Amanlou, M., Shahbazi, S., and Bayat, M., IJPS, 2010, vol. Souri, E., Amanlou, M., Farsam, H., and Afshari, A., Chem. Souri, E., Jalalizadeh, H., Fasam, H., Ghadiri, R., and Amanlou, M., Chem. Souri, E., Jalalizadeh, H., Fasam, H., Rezwani, H., and Amanlou, M., DARU, 2005, vol. Khoshayand, M.R., Abdollahi, H., Shariatpanahi, M., Saadatfard, A., and Mohammadi, A., Spectrochim. 2433.īouhsain, Z., Garrigues, S., and De La Guardia, M., Fresenius J. 809.ĭominguez-Vidal, A., Garcia Reyes, J.F., Ortega-Barrales, P., and Molina-Diaz, A., Anal. Palabiyik, I.M., Dinc, E., and Onur, F., J. 45.Īyora Canada, M.J., Pascual Reguera, M.I., Ruiz Medina, A., Fernandez de Cordova, M.L., and Molina Diaz, A., J. 857.īispo, M.S., Veloso, M.C., Pinheiro, H.L., De Oliveria, R.F., Reis, J.O., and De Andrade, J.B., J. Whelan, M.R., Ford, J.L., and Powell, M.W., J. Marin, A., Garcia, E., Garcia, A., and Barbas, C., J. 83.ĭiamond, S., Balm, T.K., and Freitag, F.G., Clin. The method was successfully applied to the simultaneous determination of acetaminophen, ibuprofen and caffeine in pharmaceutical dosage forms without any interference from excipients and there was no need to any prior separation before analysis.īrunton, L., Parker, K., Blumenthal, D., and Buxton, I., Goodman and Gillman’s Manual of Pharmacology and Therapeutics, New York City: Mc Graw-Hill Medical Publishing Division, 2008.įredholm, B.B., Battig, K., Holmen, J., Nehlig, A., and Zvatau, E.E., Pharmacol. ![]() ![]() The within-day and between-day precision and accuracy of the proposed method were acceptable (CV < 3% and error < 2%) for all three components and the proposed method was satisfactory for quality control purposes. The method was found to be linear ( r 2 > 0.998) in the range of (μg/mL) 5–50 for acetaminophen, 5–30 for ibuprofen and 1–7 for caffeine in the presence of other compounds. Ibuprofen and caffeine were determined at wavelengths of 235 and 300 nm using the second order (Δλ = 21.0) and fourth order (Δλ = 27.0) derivative spectra. Under the optimized conditions, determination of acetaminophen was performed at wavelengths of 311 and 270 nm using the third order (Δλ = 24.5) and fourth order (Δλ = 12.0) derivative spectra, respectively. The derivative spectra of standard solutions of each compound were obtained at different orders to find out the suitable zero-crossing points. A zero-crossing derivative spectrophotometric method was used for the simultaneous determination of acetaminophen, ibuprofen and caffeine.
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